Peer, Achiel Van: search on Z-Library

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1

A Preclinical Bioavailability Strategy for Decisions on Clinical Drug Formulation Development: an In Depth Analysis

Van Den Bergh, An, Van Hemelryck, Sandy, Bevernage, Jan, Van Peer, Achiel, Brewster, Marcus, Mackie, Claire, Mannaert, Erik

Journal:

Molecular Pharmaceutics

Year:

2018

Language:

english

File:

PDF, 1.77 MB

english, 2018

2

Role of modelling and simulation in Phase I drug development

Leon Aarons, Mats O. Karlsson, France Mentré, Ferdinand Rombout, Jean-Louis Steimer, Achiel van Peer

Journal:

European Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001

3

Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability

Vangelis Karalis, Panos Macheras, Achiel Van Peer, Vinod P. Shah

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 138 KB

english, 2008

4

The Pharmacokinetics of Alfentanil After Normothermic and Hypothermic Cardiopulmonary Bypass

Petros, Andy, Dunne, Nuala, Mehta, Raj, Dore, Caroline J., Van Peer, Achiel, Gillbe, Charles, Macrae, Duncan

Journal:

Anesthesia & Analgesia

Year:

1995

Language:

english

File:

PDF, 1.21 MB

english, 1995

5

Including Information on the Therapeutic Window in Bioequivalence Acceptance

Tom Jacobs, Filip De Ridder, Sarah Rusch, Achiel Van Peer, Geert Molenberghs, Luc Bijnens

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 269 KB

english, 2008

6

Use of physiologically relevant biopharmaceutics tools within the pharmaceutical industry and in regulatory sciences: Where are we now and what are the gaps?

Flanagan, Talia, Van Peer, Achiel, Lindahl, Anders

Journal:

European Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 617 KB

english, 2016

7

From preclinical to human – prediction of oral absorption and drug–drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example

Vikash Kumar Sinha, Jan Snoeys, Nancy Van Osselaer, Achiel Van Peer, Claire Mackie, Donald Heald

Journal:

Biopharmaceutics & Drug Disposition

Year:

2012

Language:

english

File:

PDF, 238 KB

english, 2012

8

Alfentanil kinetics in the elderly

Helmers, Henk, Van Peer, Achiel, Woestenborghs, Robert, Noorduin, Henk, Heykants, Jos

Journal:

Clinical Pharmacology & Therapeutics

Year:

1984

Language:

english

File:

PDF, 259 KB

english, 1984

9

Influence of itraconazole on the pharmacokinetics and electrocardiographic effects of astemizole

Romain A. Lefebvre, Achiel Van Peer, Robert Woestenborghs

Journal:

British Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 242 KB

english, 1997

10

Investigation of the Pharmacokinetics and Analgesic Effects of an Intramuscular Injection of Sustained-Release Sufentanil for Postoperative Pain

BERGMANS, GERARD, VANACKER, BERNARD, AKEN, HUGO VAN, NOORDUIN, HENK, PEER, ACHIEL VAN, GRYSEELS, S. JORIS, VERHAMME, BRUNO

Journal:

Survey of Anesthesiology

Year:

1995

File:

PDF, 78 KB

1995

11

Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects

Huang, May-Lynn, Peer, Achiel Van, Woestenborghs, Robert, De Coster, Roland, Heykants, Jos, Jansen, Arno A I, Zylicz, Zbigniew, Visscher, Hendrik W, Jonkman, Jan H G

Journal:

Clinical Pharmacology & Therapeutics

Year:

1993

Language:

english

File:

PDF, 1.50 MB

english, 1993

12

Pharmacokinetics of the immunomodulatory 1,2-O-isopropylidene-3-O-3′-(N′,N′-dimethyl-amino-n-propyl)-D-glucofuranose hydrochloride in normal human volunteers

Edward R. Garrett, Achiel Van Peer, Paul Altmayer, Waldtraut Schuermann, Peter Lücker

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1982

Language:

english

File:

PDF, 788 KB

english, 1982

13

Modelling and Simulation in the Development and use of Anti-Cancer Agents: An Underused Tool?

Ferdinand Rombout, Leon Aarons, Mats Karlsson, Anthony Man, France Mentré, Peter Nygren, Amy Racine, Hans Schaefer, Jean-Louis Steimer, Iñaki Troconiz, Achiel van Peer

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2004

Language:

english

File:

PDF, 292 KB

english, 2004

14

The Pharmacokinetics of Alfentanil After Normothermic and Hypothermic Cardiopulmonary Bypass

Petros, Andy, Dunne, Nuala, Mehta, Raj, Dore, Caroline J., Van Peer, Achiel, Gillbe, Charles, Macrae, Duncan

Journal:

Anesthesia & Analgesia

Year:

1995

Language:

english

File:

PDF, 1.21 MB

english, 1995

15

Linearity of Pharmacokinetics and Model Estimation of Sufentanil

Gepts, Elisabeth, Shafer, Steven L., Camu, Frederic, Stanski, Donald R., Woestenborghs, Robert, Van Peer, Achiel, Heykants, Jos J.P.

Journal:

Year:

1995

File:

PDF, 8.01 MB

1995

16

The Pharmacokinetics of Alfentanil After Normothermic and Hypothermic Cardiopulmonary Bypass

PETROS, ANDY, DUNNE, NUALA, MEHTA, RAJ, DORE, CAROLINE, PEER, ACHIEL VAN, GILLBE, CHARLES, MACRAE, DUNCAN

Journal:

Survey of Anesthesiology

Year:

1996

File:

PDF, 79 KB

1996

17

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro–In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound

T’jollyn, Huybrecht, Snoeys, Jan, Van Bocxlaer, Jan, De Bock, Lies, Annaert, Pieter, Van Peer, Achiel, Allegaert, Karel, Mannens, Geert, Vermeulen, An, Boussery, Koen

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 515 KB

english, 2017

18

Safety and pharmacokinetics of the neuroprotective drug lubeluzole in patients with ischemic stroke

Jacques De Keyser, Vera Van de Velde, Ronald L.L.A. Schellens, Ludwig Hantson, Luc Tristmans, Jan Gheuens, Achiel Van Peer, Robert Woestenborghs, Cornelius L. Franke, Jos van Gorp

Journal:

Clinical Therapeutics

Year:

1997

Language:

english

File:

PDF, 545 KB

english, 1997

19

The successes and failures of physiologically based pharmacokinetic modeling: there is room for improvement

Poggesi, Italo, Snoeys, Jan, Van Peer, Achiel

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2014

Language:

english

File:

PDF, 339 KB

english, 2014

20

A Model with Separate Hepato-Portal Compartment ("First-Pass" Model): Fitting to Plasma Concentration-Time Profiles in Humans

Vladimir Piotrovskij, Achiel Van Peer

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 645 KB

1997

21

Properties, stability, assay, and preliminary pharmacokinetics of the immunomodulatory 1,2-O-Isopropylidene-3-O-3′(N′, N′-Dimethylamino-n-propyl)-D-Glucofuranose hydrochloride

Edward R. Garrett, Achiel van Peer, Helmy Mahrous, Waldtraut Schuermann

Journal:

Journal of Pharmaceutical Sciences

Year:

1982

Language:

english

File:

PDF, 1.08 MB

english, 1982

22

Pharmacokinetics and tissue distribution of astemizole in the dog

Marcel Michiels, Achiel van Peer, Robert Woestenborghs, Jozef Heykants

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 519 KB

english, 1986

23

Investigation of the pharmacokinetics and analgesic effects of an intramuscular injection of sustained-release sufentanil for postoperative pain: An open study

Bergmans, Gerard, Vanacker, Bernard, Van Aken, Hugo, Noordui, Henk, Van Peer, Achiel, Gryseels, Joris, Verhamme, Bruno

Journal:

Journal of Clinical Anesthesia

Year:

1994

Language:

english

File:

PDF, 784 KB

english, 1994

24

Molecular Properties Determining Unbound Intracellular and Extracellular Brain Exposure of CNS Drug Candidates

Loryan, Irena, Sinha, Vikash, Mackie, Claire, Van Peer, Achiel, Drinkenburg, Wilhelmus H., Vermeulen, An, Heald, Donald, Hammarlund-Udenaes, Margareta, Wassvik, Carola M.

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 1.81 MB

english, 2015

25

Fentanyl Delivery from an Electrotransport System: Delivery is a Function of Total Current, Not Duration of Current

Gupta, Suneel K., Bernstein, Keith J., Noorduin, Henk, Van Peer, Achiel, Sathyan, Gayatri, Haak, Ron

Journal:

Journal of Clinical Pharmacology

Year:

1998

Language:

english

File:

PDF, 1.19 MB

english, 1998

26

Effects of demographic variables on vorozole pharmacokinetics in healthy volunteers and in breast cancer patients

Vladimir K. Piotrovsky, May-Lynn Huang, Achiel Van Peer, Christine Langenaecken

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 392 KB

english, 1998

27

Dose-proportionality, bioavailability, and steady-state kinetics of astemizole in man

Jozef Heykants, Achiel van Peer, Robert Woestenborghs, Anton Jageneau, Gabriel Vanden Bussche

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 484 KB

english, 1986

28

Predicting Oral Clearance in Humans

Vikash K. Sinha, Stefan S. De Buck, Luca A. Fenu, Johan W. Smit, Marjoleen Nijsen, Ron A. H. J. Gilissen, Achiel Van Peer, Karel Lavrijsen, Claire E. Mackie

Journal:

Clinical Pharmacokinetics

Year:

2008

Language:

english

File:

PDF, 158 KB

english, 2008

29

Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry

Dr Vikash K. Sinha, Karin Vaarties, Stefan S. De Buck, Luca. A. Fenu, Marjoleen Nijsen, Ron A. H. J. Gilissen, Wendy Sanderson, Kelly Van Uytsel, Eva Hoeben, Achiel Van Peer, Claire E. Mackie, Johan W

Journal:

Clinical Pharmacokinetics

Year:

2011

Language:

english

File:

PDF, 189 KB

english, 2011

30

Physiology-Based IVIVE Predictions of Tramadol fromin VitroMetabolism Data

T’jollyn, Huybrecht, Snoeys, Jan, Colin, Pieter, Van Bocxlaer, Jan, Annaert, Pieter, Cuyckens, Filip, Vermeulen, An, Van Peer, Achiel, Allegaert, Karel, Mannens, Geert, Boussery, Koen

Journal:

Pharmaceutical Research

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

31

Effect of Food on the Pharmacokinetics of a New Hydroxypropyl-β-Cyclodextrin Formulation of Itraconazole

Dr. Vera J.S. Van de Velde, Dr. Achiel P. Van Peer, Dr. Joseph J.P. Heykants, Mr. Robert J.H. Woestenborghs, Dr. Patricia Van Rooy, Mr. Karel L. De Beule, Dr. Geert F.M.J. Cauwenbergh

Journal:

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Year:

1996

Language:

english

File:

PDF, 450 KB

english, 1996

32

The Pharmacokinetic Properties of Topical Levocabastine

Dr Jozef Heykants,Achiel Van Peer,Vera Van de Velde…

Journal:

Clinical Pharmacokinetics

Year:

1995

Language:

english

File:

PDF, 872 KB

english, 1995

33

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation

T’jollyn, Huybrecht, Snoeys, Jan, Vermeulen, An, Michelet, Robin, Cuyckens, Filip, Mannens, Geert, Van Peer, Achiel, Annaert, Pieter, Allegaert, Karel, Van Bocxlaer, Jan, Boussery, Koen

Journal:

The AAPS Journal

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

34

Variability and Impact on Design of Bioequivalence Studies

Achiel Van Peer

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2010

Language:

english

File:

PDF, 136 KB

english, 2010

35

Alfentanil infusions for peroperative and postoperative analgesia

Henk Noorduin, Heather Waldron, Achiel van Peer, Gabriel Vanden Bussche

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 361 KB

english, 1986

36

A Combined Specific Target Site Binding and Pharmacokinetic Model to Explore the Non-linear Disposition of Draflazine

Eric Snoeck, Philippe Jacqmin, Achiel Van Peer, Meindert Danhof

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1999

Language:

english

File:

PDF, 1.52 MB

english, 1999

37

Pharmacokinetics of Ritanserin in Patients Undergoing Hemodialysis

Zazgornik, Jan, Kuska, Jadwiga, Kokot, Franciszek, Koch, Sonja, Van Peer, Achiel, Huang, M. L., Heykants, Jos

Journal:

Journal of Clinical Pharmacology

Year:

1991

Language:

english

File:

PDF, 555 KB

english, 1991

38

Pharmacokinetics of Orally Administered Levocabastine in Patients with Renal Insufficiency

Zazgornik, Jan, Huang, May Lynn, Van Peer, Achiel, Woestenborghs, Robert, Heykants, Jos, Stephen, Adrian

Journal:

Journal of Clinical Pharmacology

Year:

1993

Language:

english

File:

PDF, 711 KB

english, 1993

39

Pharmacokinetics of intravenous and oral 1,2-O-isopropylidene-3-O-3′-(N′,n′-dimethylamino-N-propyl)-D-glucofuranose hydrochloride in the dog as a function of dose and characterization of metabolites

Edward R. Garrett, Achiel Van Peer

Journal:

Journal of Pharmaceutical Sciences

Year:

1983

Language:

english

File:

PDF, 1.27 MB

english, 1983

40

Physiologically-Based PK/PD Modelling of Therapeutic Macromolecules

Peter Thygesen, Panos Macheras, Achiel Van Peer

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 224 KB

english, 2009

41

Galantamine Population Pharmacokinetics in Patients with Alzheimer's Disease: Modeling and Simulations

Piotrovsky, Vladimir, Van Peer, Achiel, Van Osselaer, Nancy, Armstrong, Martin, Aerssens, Jeroen

Journal:

Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

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